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    References. References are publications that support the biological activity of the product. Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392 PMID: 16111712 Maher et al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.

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    2-Deoxy-D-Glucose Supplier | CAS 154-17-6 | Focus Biomolecules

    2-Deoxy-D-glucose (154-17-6) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-Deoxy-D-glucose competitively inhibits glucose uptake via its metabolite 2-Deoxy-D-glucose-6-phosphate, .

    Tritiated 2‐deoxy‐D‐glucose: A high‐resolution marker for .

    Tritiated 2‐deoxy‐D‐glucose: A high‐resolution marker for autoradiographic localization of brain metabolism. Ronald P. Hammer Jr. Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20205 . due perhaps to selective fixation and retention of intracellular labeled 2‐deoxy‐glycogen. A series of [3 H

    A phase I dose-escalation trial of 2- deoxy- d-glucose .

    Dec 11, 2012· Purpose. This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy-d-glucose (2DG) in combination with docetaxel, in patients with advanced solid tumors.

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    Scheme 3. Zakrzewski and Cheuk have utilised 2-deoxy-D-ribose in a synthesis of the four diastereomeric syn- and anti-3,5-dihydroxy-6-heptenoates; one of which is depicted in Scheme 4.These enantiomerically pure intermediates form useful intermediates for the synthesis of polyols. 2-Deoxy-D-ribose has even been used in a short and efficient synthesis of the enantiomer, 2-deoxy-L-ribose, in a .

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    2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 …

    Deoxy-D-glucose, 2-[1,2-3H(N)]-, 250µCi (9.25MBq .

    2-Deoxy-D-glucose, labeled with tritium at C1/C2. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized.

    2-Deoxy-D-Glucose (2dg) | mcrc4

    2-Deoxy-D-Glucose (2dg) Posted on July 10, 2013 by Ren. 2DG is a funky molecule that I came across last month and have started taking it last week as an IV infusion. 2DG is a modified version of Glucose having a hydroxyl group replaced with hydrogen. The simple modification means that it can not undergo glycolysis, the fermentation step used by .

    2-Deoxy-D-glucose ≥98% (GC), crystalline | Sigma-Aldrich

    2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP.

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    This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production .

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    2-deoxyglucose (2DG) acts as an inhibitor of glucose metabolism since it inhibits hexokinase, which is the first limiting factor enzyme of glycolysis.

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    Means ± SD are presented. ( B ) Glucose uptake was assessed in non-stimulated (NS) and TCR-stimulated T cell populations (1 × 10 6 ) by incubation with 2-deoxy-D[1- 3 H]glucose (2-DG, 0.1 mM) for 10 min at RT. Uptake is expressed as mean counts per minute (CPM) for triplicate samples in 1 of 3 representative experiments; p

    A Phase I/II Trial of 2-Deoxyglucose (2DG) for the .

    Subjects will be asked to participate in this clinical trial to examine the safety of 2-deoxyglucose (an agent which is quite similar to glucose) in the treatment of solid tumors and hormone refractory prostate cancer. This agent works by blocking the metabolism of glucose in the cells of the body .

    2-Deoxy-D-glucose | 154-17-6

    2-Deoxy-D-glucose Chemical Properties,Uses,Production Chemical Properties white to light yellow crystal powde Uses 2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis.

    2-Deoxy-D-Glucose - an overview | ScienceDirect Topics

    25.3.8 Glucose Utilization. The 2-deoxy-glucose technique was used to identify sites of functional abnormality in the dt rat. A total of 62 sites within the central nervous system were compared between dt rats and their normal littermates (Brown and Lorden, 1989). Several brain regions showed marked differences between mutant and normal rats .

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    Product Name 2-Deoxy-D-glucose | Sigma-Aldrich

    Summary: This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward .

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    Description: Storage:This product shall be sealed to preserve. This product is crystallize solid.Soluble in water and ethanol.The α type's melting point is 134~136℃.The β type's melting point is 142~144℃.Used in biochemical study.

    Fludeoxyglucose (18F) - Wikipedia

    The 2-hydroxyl group (—OH) in normal glucose is needed for further glycolysis (metabolism of glucose by splitting it), but [18 F]FDG is missing this 2-hydroxyl. Thus, in common with its sister molecule 2-deoxy-D-glucose, FDG cannot be further metabolized in cells.

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    2-Deoxy-D-glucose - Wikipedia

    2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

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    Our production 2-Deoxy-D-Glucose appears white crystal powder. Specific Rotation is 47°±1 and its content is above 98%. It has been used widely to inhibit herpes simplex and fluenza, RNA DNA enveloped viruses etc. 2-Deoxy-D-Glucose is a new natural antibiotics. It can inhibit the growth of various pathogenic microorganism.

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